In scientific studies exactly where cerivastatin sodium has been administered concomitantly with cholestyramine, no adverse reactions one of a kind to this mixture or Along with Those people previously described for this class of medicine had been reported. Myopathy and rhabdomyolysis (with or devoid of acute renal failure) are already reported when HMG-CoA reductase inhibitors are applied in combination with immunosuppressive medications, fibric acid derivatives, erythromycin, azole antifungals or lipid-decreasing doses of nicotinic acid.

Cholesterol and triglycerides circulate as A part of lipoprotein complexes all through the bloodstream.

CYCLOSPORINE: The only dose pharmacokinetics of 0.2 mg of cerivastatin in balanced subjects was in comparison with the pharmacokinetics of single and multiple doses in renal transplant clients who have been at regular-point out with respect to cyclosporine.

Cerivastatin really should be administered to Ladies of child-bearing age only when these types of individuals are really unlikely to conceive and have already been knowledgeable of the likely dangers. Should the affected person will become Expecting though taking this drug, cerivastatin must be discontinued as well as patient must be apprised with the potential hazard for the fetus.

The blended usage of cerivastatin and gemfibrozil is contraindicated as a result of a risk website for rhabdomyolysis (see CONTRAINDICATIONS).

CIMETIDINE: Cerivastatin plasma concentrations weren't affected by co-administration of cimetidine.

Pregnancy Group X: (See CONTRAINDICATIONS): Cerivastatin caused a major boost in incomplete ossification in the lumbar Heart of the vertebrae in rats at an oral dose of 0.72 mg/kg. Cerivastatin did not bring about any anomalies or malformations in rabbits at oral doses around 0.

The merged utilization of HMG-CoA inhibitors and fibrates frequently should be avoided. Using fibrates by itself may very well be associated with myopathy which includes rhabdomyolysis and linked renal failure.

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Outcomes of scientific trials with medicine With this class are actually inconsistent regarding drug impact on basal and reserve steroid stages. The effects of HMG-CoA reductase inhibitors on male fertility have not been studied in enough numbers of male people. The consequences, if any, about the pituitary-gonadal axis in pre-menopausal Ladies are not known.

Coumarin Anticoagulants: Coadministration of warfarin and cerivastatin experienced no effect on the plasma concentration of possibly agent.

Muscle Outcomes: Myopathy, described as muscle aching or muscle weak point, related to boosts in plasma creatine phosphokinase (CPK) values to better than 10 situations the ULN was unusual (

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While thus far hypersensitivity syndrome hasn't been called these kinds of, cerivastatin ought to be discontinued if hypersensitivity is suspected.

Effect on Lens: Present info from clinical trials don't show an adverse impact of cerivastatin around the human lens.